List of Figures

1.1

A. Main parts of the brain B. Lobes of the brain C. A neuron

and its parts. The figure was partly generated using Servier

Medical Art, provided by Servier, licensed under a Creative

Commons Attribution 4.0 unported license. . . . . . . . . . .

2

1.2

A four-quarter brain model. . . . . . . . . . . . . . . . . . . .

6

1.3

Brain diseases and disorders included in this chapter. . . . . .

7

3.1

Selected

examples

of

soluble

molecules

and

membrane-

associated proteins in invasive, immunosuppressive and angio-

genic network of immune system cells and tumors. BLACK

arrows mark activation of target cells with relevant factors.

BLUNT BLACK arrows point out inhibitory activity through

mentioned factors. GREY arrows indicate factors involved

in angiogenesis. DASHED arrows represent immune activity

against the tumor. DASHED GREY arrows show factors in di-

rect effect on tumor cells to promote invasion. The figure was

generated using Servier Medical Art, provided by Servier, li-

censed under a Creative Commons Attribution 4.0 unported

license.

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

77

3.2

BBB of capillaries and ECM in the brain. The figure was partly

generated using Servier Medical Art, provided by Servier, li-

censed under a Creative Commons Attribution 4.0 unported

license. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

83

3.3

Summary of the most common GBM (hetero)spheroid forma-

tion techniques. A. Hanging drop, B. Low attachment wells, C.

Agitation-based systems, D. Magnetic systems, E. Scaffolds, F.

Microfluidic systems. . . . . . . . . . . . . . . . . . . . . . . .

86

4.1

Anatomical planes. The MRI dataset that was made available

as open source on Kaggle was used to create this figure [5].

.

117

4.2

Original and skull stripped MRI images. The original MRI im-

age featured in this figure was selected from the dataset avail-

able as open source on Kaggle [5].

. . . . . . . . . . . . . . .

120

4.3

Histogram of an image.

. . . . . . . . . . . . . . . . . . . . .

123

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